We published a paper in 2001 with the first digital light sheet macroscope, allowing to scan small objects rapidly in three dimensions. We even patented the use of digital cameras for 3D light sheet based reconstruction, the use of lasers for light sheets, etc. However, at the time neither the major microscope producers nor the scientific community cared much. Digital light sheet microscopy has since gained a bit more attention….
For fun, here are a few pictures from some of the insects I used to work with:
Or the cheesy animated gifs from the early days: